Western Blot (WB)
(GUCY2F Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GUCY2F antibody detected the GUCY2F protein (arrow).)
Rabbit GUCY2F Polyclonal Antibody | anti-GUCY2F antibody
GUCY2F Antibody (C-term)
Western Blot (WB)
(GUCY2F Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GUCY2F antibody detected the GUCY2F protein (arrow).)
Western Blot (WB)
(GUCY2F Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GUCY2F antibody detected the GUCY2F protein (arrow).)
found predominantly in photoreceptors in the retina. The encoded
protein is thought to be involved in resynthesis of cGMP after
light activation of the visual signal transduction cascade,
allowing a return to the dark state. This protein is a single-pass
type I membrane protein. Defects in this gene may be a cause of
X-linked retinitis pigmentosa.
Helten, A., et al. J. Neurochem. 103(4):1439-1446(2007)
Wood, L.D., et al. Hum. Mutat. 27(10):1060-1061(2006)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Laura, R.P., et al. Biochemistry 37(32):11264-11271(1998)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]
Uniprot Description
GUCY2F: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Lyase; Protein kinase, dual-specificity (receptor); Guanylyl cyclase; Protein kinase, RGC; Kinase, protein; EC 4.6.1.2; Membrane protein, integral; Nucleotide Metabolism - purine; Receptor, misc.; RGC group; RGC family
Chromosomal Location of Human Ortholog: Xq22
Cellular Component: nuclear outer membrane; integral to plasma membrane
Molecular Function: guanylate cyclase activity; protein homodimerization activity; GTP binding; protein heterodimerization activity; receptor activity; ATP binding; protein kinase activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; cGMP biosynthetic process; regulation of rhodopsin mediated signaling; visual perception; receptor guanylyl cyclase signaling pathway; protein amino acid phosphorylation
Research Articles on GUCY2F
Similar Products
Product Notes
The GUCY2F gucy2f (Catalog #AAA9213230) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 828-856. The GUCY2F Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's GUCY2F can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GUCY2F gucy2f for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GUCY2F, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
