Rabbit GSTO2 Polyclonal Antibody | anti-GSTO2 antibody

GSTO2 Polyclonal Antibody

Cat. Num. AAA3011335

• Gene Names: GSTO2; GSTO 2-2; bA127L20.1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GSTO2; Polyclonal Antibody; GSTO2 Polyclonal Antibody; bA127L20.1; Glutathione S transferase like protein; Glutathione S transferase omega 2; Glutathione S-transferase omega-2; GSTO 2; GSTO-2; GSTO2_HUMAN; anti-GSTO2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GSTO2 polyclonal antibody detects endogenous levels of GSTO2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 209

• Applicable Applications for anti-GSTO2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human GSTO2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GSTO2 polyclonal antibody)

Related Product Information for anti-GSTO2 antibody

GSTO1 (glutathione S-transferase omega 1), also known as p28 or GSTTLp28, is a 241 amino acid protein that localizes to the cytoplasm and contains both an N-terminal and a C-terminal GST domain. Expressed ubiquitously with highest expression in heart, liver and skeletal muscle, GSTO1 exists as a homodimer that functions as both a glutathione-dependent thiol transferase and a dehydroascorbate reductase. Specifically, GSTO1 catalyzes the reaction of glutathione with a wide variety of organic compounds to form thioethers, a process that is essential for the metabolism and detoxification of a variety of xenobiotics and carcinogens. Polymorphisms in the gene encoding GSTO1 may be associated with the development of childhood acute lymphoblastic leukemia, Parkinson's disease and Alzheimer disease. GSTO2 (glutathione S-transferase omega-2) is related to GSTO1 and is expressed in a variety of tissues throughout the body where it functions to catalyze the conversion of RX and glutathione to HX and R-S-glutathione.

NCBI and Uniprot Product Information

• NCBI GI #: 300360567
• NCBI GeneID: 119391
• NCBI Accession #: NP_001177942.1
• NCBI GenBank Nucleotide #: NP_001177942.1
• UniProt Accession #: Q9H4Y5
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: glutathione S-transferase omega-2 isoform 2
• NCBI Official Synonym Full Names: glutathione S-transferase omega 2
• NCBI Official Symbol: GSTO2
• NCBI Official Synonym Symbols: GSTO 2-2; bA127L20.1
• NCBI Protein Information: glutathione S-transferase omega-2
• UniProt Protein Name: Glutathione S-transferase omega-2
• Protein Family: Glutathione S-transferase
• UniProt Gene Name: GSTO2
• UniProt Synonym Gene Names: GSTO-2; GSTO 2-2; MMA(V) reductase
• UniProt Entry Name: GSTO2_HUMAN

NCBI Description

The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Uniprot Description

GSTO2: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.20.4.2; Transferase; EC 2.5.1.18; EC 1.8.5.1; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: cytosol

Molecular Function: glutathione transferase activity; glutathione dehydrogenase (ascorbate) activity; methylarsonate reductase activity; oxidoreductase activity

Biological Process: vitamin metabolic process; xenobiotic metabolic process; L-ascorbic acid metabolic process; water-soluble vitamin metabolic process