Rabbit GSTA2 Polyclonal Antibody | anti-GSTA2 antibody

GSTA2 Rabbit Polyclonal

Cat. Num. AAA769919

• Gene Names: GSTA2; GST2; GTA2; GTH2; GSTA2-2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GSTA2; Polyclonal Antibody; GSTA2 Rabbit Polyclonal; anti-GSTA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 222

• Applicable Applications for anti-GSTA2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Glutathione S-transferase alpha 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS769919 (GSTA2 antibody) at dilution of 1:100)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS769919 (GSTA2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 215276987
• NCBI GeneID: 2939
• NCBI Accession #: NP_000837.3
• NCBI GenBank Nucleotide #: NM_000846.4
• Molecular Weight: 25,664 Da
• NCBI Official Full Name: glutathione S-transferase A2
• NCBI Official Synonym Full Names: glutathione S-transferase alpha 2
• NCBI Official Symbol: GSTA2
• NCBI Official Synonym Symbols: GST2; GTA2; GTH2; GSTA2-2
• NCBI Protein Information: glutathione S-transferase A2
• UniProt Protein Name: Glutathione S-transferase A2
• Protein Family: Glutathione S-transferase
• UniProt Gene Name: GSTA2
• UniProt Synonym Gene Names: GST2
• UniProt Entry Name: GSTA2_HUMAN

NCBI Description

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

Uniprot Description

GSTA2: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family.

Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: cytosol

Molecular Function: glutathione transferase activity; protein binding

Biological Process: epithelial cell differentiation; glutathione metabolic process