Rabbit GSR Polyclonal Antibody | anti-GSR antibody

GSR Rabbit Polyclonal

Cat. Num. AAA769914

• Gene Names: GSR; HEL-75; HEL-S-122m
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GSR; Polyclonal Antibody; GSR Rabbit Polyclonal; anti-GSR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 440

• Applicable Applications for anti-GSR antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Glutathione reductase
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunofluorescence (IF)

(Immunofluorescent analysis of MCF-7 cells, using MBS769914 (GSR antibody) at 1:25 dilution)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS769914 (GSR antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 305410793
• NCBI GeneID: 2936
• NCBI Accession #: NP_001182033.1
• NCBI GenBank Nucleotide #: NM_001195104.1
• Molecular Weight: 47,267 Da
• NCBI Official Full Name: glutathione reductase, mitochondrial isoform 4
• NCBI Official Synonym Full Names: glutathione reductase
• NCBI Official Symbol: GSR
• NCBI Official Synonym Symbols: HEL-75; HEL-S-122m
• NCBI Protein Information: glutathione reductase, mitochondrial
• UniProt Protein Name: Glutathione reductase, mitochondrial
• Protein Family: Glutathione reductase
• UniProt Gene Name: GSR
• UniProt Synonym Gene Names: GLUR; GRD1; GR; GRase
• UniProt Entry Name: GSHR_HUMAN

NCBI Description

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

Uniprot Description

GSR: a class-I pyridine nucleotide-disulfide oxidoreductase. Maintains high levels of reduced glutathione in the cytosol. Alternative initiation results in a mitochondrial and a cytoplasmic isoform.

Protein type: Oxidoreductase; EC 1.8.1.7; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cytosol; external side of plasma membrane; mitochondrial matrix

Molecular Function: electron carrier activity; FAD binding; glutathione-disulfide reductase activity; NADP binding

Biological Process: cell redox homeostasis; glutathione metabolic process; nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species