Rabbit GSK3 BETA Polyclonal Antibody | anti-GSK3 BETA antibody
RABBIT ANTI GSK3 BETA (pSer9)
GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase.
Phosphorylation of serine-9 inhibits GSK3 beta function.
Purified IgG - liquid
Western Blotting: Maximum Dilution: 1/1000; Application Note: Special conditions apply. See *
50% Glycerol
0.01% Bovine Serum Albumin
Buffer Solution
Shelf Life: 12 months from date of despatch.
NCBI and Uniprot Product Information
NCBI Description
mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD, Feb 2006]
Uniprot Description
GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation
Protein type: Protein kinase, CMGC; EC 2.7.11.1; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; GSK family; GSK subfamily
Cellular Component: centrosome; protein complex; dendritic spine; cytosol; beta-catenin destruction complex; ribonucleoprotein complex; lipid raft; nucleoplasm; growth cone; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus
Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; transcription factor binding; protein kinase activity; integrin binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; NF-kappaB binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding
Biological Process: glycogen metabolic process; circadian rhythm; fat cell differentiation; negative regulation of MAP kinase activity; genetic imprinting; re-entry into mitotic cell cycle; positive regulation of protein binding; positive regulation of apoptosis; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; establishment and/or maintenance of cell polarity; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; myoblast fusion; ER overload response; response to drug; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; peptidyl-serine phosphorylation; negative regulation of neuron maturation; organ morphogenesis; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; phosphorylation; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity
Research Articles on GSK3 BETA
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Product Notes
The GSK3 BETA gsk3b (Catalog #AAA221520) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI GSK3 BETA (pSer9) reacts with Bovine (Expected from Sequence), Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Xenopus (Expected from Sequence), Zebrafish (Expected from S and may cross-react with other species as described in the data sheet. AAA Biotech's GSK3 BETA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB)*. Western Blot: This item detects a band of approximately 46kDa in rat cortex cell lysates. Western Blotting: Maximum Dilution: 1/1000; Application Note: Special conditions apply. See *. Researchers should empirically determine the suitability of the GSK3 BETA gsk3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSK3 BETA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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