Rabbit anti-Human, Mouse GSDMA Polyclonal Antibody | anti-GSDMA antibody
GSDMA Antibody
Gene Names
GSDMA; GSDM; FKSG9; GSDM1
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
GSDMA; Polyclonal Antibody; GSDMA Antibody; FKSG9; Gasdermin 1; Gasdermin A; Gasdermin-1; Gasdermin-A; GSDM; GSDM1; GSDMA_HUMAN; anti-GSDMA antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
GSDMA Antibody detects endogenous levels of GSDMA.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-GSDMA antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human GSDMA.
Conjugation
Unconjugated
Similarity
Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain. Belongs to the gasdermin family.
Subunit Structure
The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.
Tissue Specificity
Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells.
Function
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4, 5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown (Probable).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-GSDMA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,365 Da
NCBI Official Full Name
gasdermin-A
NCBI Official Synonym Full Names
gasdermin A
NCBI Official Symbol
GSDMA
NCBI Official Synonym Symbols
GSDM; FKSG9; GSDM1
NCBI Protein Information
gasdermin-A; gasdermin 1; gasdermin-1
UniProt Protein Name
Gasdermin-A
Protein Family
UniProt Gene Name
GSDMA
UniProt Synonym Gene Names
GSDM; GSDM1
UniProt Entry Name
GSDMA_HUMAN
Uniprot Description
GSDMA: Induces apoptosis. Belongs to the gasdermin family.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 17q21.1
Cellular Component: perinuclear region of cytoplasm
Biological Process: apoptosis
Research Articles on GSDMA
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Product Notes
The GSDMA gsdma (Catalog #AAA9629750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GSDMA Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GSDMA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the GSDMA gsdma for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSDMA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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