Rabbit GRM3 Polyclonal Antibody | anti-GRM3 antibody

GRM3 Polyclonal Antibody

Cat. Num. AAA2529583

• Gene Names: Grm3; mGlu3; Gprc1c; mGluR3; 0710001G23Rik
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Antigen affinity purification
• Synonyms: GRM3; Polyclonal Antibody; GRM3 Polyclonal Antibody; GLUR3; mGlu3; GPRC1C; MGLUR3; anti-GRM3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 453

• Applicable Applications for anti-GRM3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Synthetic peptide of human GRM3
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Mouse brain tissue using GRM3 Polyclonal Antibody at dilution of 1:250)

Related Product Information for anti-GRM3 antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

NCBI and Uniprot Product Information

• NCBI GI #: 37994615
• NCBI GeneID: 108069
• Molecular Weight: 99,114 Da
• NCBI Official Full Name: Grm3 protein, partial
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 3
• NCBI Official Symbol: Grm3
• NCBI Official Synonym Symbols: mGlu3; Gprc1c; mGluR3; 0710001G23Rik
• NCBI Protein Information: metabotropic glutamate receptor 3; G protein-coupled receptor, family C, group 1, member C
• UniProt Protein Name: Metabotropic glutamate receptor 3
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: Grm3
• UniProt Synonym Gene Names: Gprc1c; Mglur3; mGluR3
• UniProt Entry Name: GRM3_MOUSE

Uniprot Description

mGluR3: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: presynaptic membrane; postsynaptic membrane; neuron projection; membrane; axon; integral to plasma membrane; postsynaptic density; plasma membrane; integral to membrane; presynaptic active zone; dendritic spine

Molecular Function: G-protein coupled receptor activity; signal transducer activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity

Biological Process: regulation of synaptic transmission; G-protein coupled receptor protein signaling pathway; synaptic transmission, glutamatergic; regulation of synaptic transmission, glutamatergic; regulation of sensory perception of pain; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction; sensory perception of pain