Rabbit anti-Human GRM1 Polyclonal Antibody | anti-GRM1 antibody

GRM1 Polyclonal Antibody

Cat. Num. AAA3007039

• Gene Names: GRM1; MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GRM1; Polyclonal Antibody; GRM1 Polyclonal Antibody; Metabotropic glutamate receptor 1; mGluR1; GPRC1A; MGLUR1; anti-GRM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GRM1 polyclonal antibody detects endogenous levels of GRM1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1194

• Applicable Applications for anti-GRM1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human GRM1
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GRM1 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysate)

Related Product Information for anti-GRM1 antibody

The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-1, which can form a homodimer acts as a receptor for glutamate. It may also be involved in glutamate activity in the CNS.

NCBI and Uniprot Product Information

• NCBI GI #: 311033443
• NCBI GeneID: 2911
• UniProt Accession #: Q13255
• Molecular Weight: ~ 132kDa
• NCBI Official Full Name: Metabotropic glutamate receptor 1
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 1
• NCBI Official Symbol: GRM1
• NCBI Official Synonym Symbols: MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85
• NCBI Protein Information: metabotropic glutamate receptor 1
• UniProt Protein Name: Metabotropic glutamate receptor 1
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM1
• UniProt Synonym Gene Names: GPRC1A; MGLUR1; mGluR1
• UniProt Entry Name: GRM1_HUMAN

NCBI Description

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Uniprot Description

mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; nucleus

Molecular Function: G-protein coupled receptor activity; protein binding; glutamate receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; protein kinase C activation; metabotropic glutamate receptor signaling pathway; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain

Disease: Spinocerebellar Ataxia, Autosomal Recessive 13