Rabbit anti-Rat GRIN1 Polyclonal Antibody | anti-GRIN1 antibody

GRIN1, glutamate receptor, ionotropic, N-methyl D-aspartate 1, NMDA1, NMDAR1, NR1, N-methyl-D-aspartate receptor channel, subunit zeta-1, NMDA receptor 1, glutamate [NMDA] receptor subunit zeta 1NMDA 1 Receptor, C1 Splice Variant (NMDA R1, N-methyl-D-aspa

Cat. Num. AAA6490188

• Gene Names: Grin1; NR1; GluN1; NMDAR1
• Reactivity: Rat
• Applications: Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: GRIN1; Polyclonal Antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 1; NMDA1; NMDAR1; NR1; N-methyl-D-aspartate receptor channel; subunit zeta-1; NMDA receptor 1; glutamate [NMDA] receptor subunit zeta 1NMDA 1 Receptor; C1 Splice Variant (NMDA R1; N-methyl-D-aspa; anti-GRIN1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes the rat NMDAR1 C1 splice variant. By Western blot recognizes a protein with MW of 100kD.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-GRIN1 antibody: Western Blot (WB)
• Application Notes: WB: 1:2,000 using ECL; Applications are based on unconjugated antibody.
• Immunogen: Peptide corresponding to the C-terminus of the rat NMDAR1 C1 splice variant.
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Related Product Information for anti-GRIN1 antibody

The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

Product Categories/Family for anti-GRIN1 antibody

Antibodies; Ion Channel

References

Prybylowski, K.L. and Wolfe, B.B., Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum, Dev. Brain Res. 123:143-150, 2000. Al-Hallaq, R., Yasuda, R.P. and Wolfe, B.B.: Enrichment of NMDA NR1 splice variants and synaptic proteins in rat postsynaptic densities. J. Neurochem. 77:110-119, 2001. 1) Collingridge, G.L., Kehl, S.J. and McLennan, H., Excitatory amino acids in synaptic transmission in the Schaeffer collateral-commissural pathway of the rat hippocampus, J.Physiol.(Lond.), 335:33-46.1983. 2) Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular cloning and characterization of the rat NMDA receptor, Nature (Lond.), 354:31-37.1991. 3) Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B. and Seeburg, P., Heteromeric NMDA receptors: molecular cloning and functional distinction of subtypes, Science, 256:1217-1221.1992. 4) Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Mizuno, N., Masu, M. and Nakanishi, S., Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits, J.Biol.Chem. 5) Laurie, D.J. and Seeburg, P.H., Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA, J.Neurosci., 14:3180-3194.1994 6) Foldes, R.L., Rampersad, V. and Kamboj, R.K., Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits, Gene, 147:303-304.1994. 7) Zukin, R.S. and Bennett, M.V.L.

NCBI and Uniprot Product Information

• NCBI GI #: 396578144
• NCBI GeneID: 24408
• NCBI Accession #: NP_001257531.1
• NCBI GenBank Nucleotide #: NM_001270602.1
• UniProt Accession #: P35439; Q62646
• Molecular Weight: 101,987 Da
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 1 isoform 1b
• NCBI Official Synonym Full Names: glutamate ionotropic receptor NMDA type subunit 1
• NCBI Official Symbol: Grin1
• NCBI Official Synonym Symbols: NR1; GluN1; NMDAR1
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 1
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 1
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: Grin1
• UniProt Synonym Gene Names: Nmdar1; GluN1; NMD-R1

NCBI Description

subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD, Feb 2006]

Uniprot Description

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.