Rabbit GRB14 Polyclonal Antibody | anti-GRB14 antibody

GRB14 Polyclonal Antibody

Cat. Num. AAA2566321

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: GRB14; Polyclonal Antibody; GRB14 Polyclonal Antibody; anti-GRB14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-GRB14 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Recombinant protein of human GRB14
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of Human fetal intestine using GRB14 Polyclonal Antibody.)

Related Product Information for anti-GRB14 antibody

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-GRB14 antibody

Signal Transduction; Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 71979663
• NCBI GeneID: 2888
• NCBI Accession #: NP_004481.2
• NCBI GenBank Nucleotide #: NM_004490.2
• UniProt Accession #: Q14449; Q7Z6I1
• Molecular Weight: 60,988 Da
• NCBI Official Full Name: growth factor receptor-bound protein 14
• NCBI Official Synonym Full Names: growth factor receptor-bound protein 14
• NCBI Official Symbol: GRB14
• NCBI Protein Information: growth factor receptor-bound protein 14; GRB14 adapter protein
• UniProt Protein Name: Growth factor receptor-bound protein 14
• Protein Family: Growth factor receptor-bound protein
• UniProt Gene Name: GRB14
• UniProt Entry Name: GRB14_HUMAN

NCBI Description

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]

Uniprot Description

GRB14: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q22-q24

Cellular Component: Golgi membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; endosome membrane; cytosol

Molecular Function: SH3/SH2 adaptor activity

Biological Process: positive regulation of signal transduction; blood coagulation; signal transduction; leukocyte migration