Western Blot (WB)
(GRB10 Antibody (N-term) western blot analysis in A549,MDA-MB453,U251 cell line lysates (35ug/lane).This demonstrates the GRB10 antibody detected the GRB10 protein (arrow).)
Rabbit anti-Human GRB10 Polyclonal Antibody | anti-GRB10 antibody
GRB10 Antibody (N-term)
Western Blot (WB)
(GRB10 Antibody (N-term) western blot analysis in A549,MDA-MB453,U251 cell line lysates (35ug/lane).This demonstrates the GRB10 antibody detected the GRB10 protein (arrow).)
Western Blot (WB)
(GRB10 Antibody (N-term) western blot analysis in A549,MDA-MB453,U251 cell line lysates (35ug/lane).This demonstrates the GRB10 antibody detected the GRB10 protein (arrow).)
O'Neill T.J., et al. J. Biol. Chem. 271:22506-22513(1996).
Frantz J.D., et al. J. Biol. Chem. 272:2659-2667(1997).
Dong L.Q., et al. J. Biol. Chem. 272:29104-29112(1997).
Nantel A., et al. J. Biol. Chem. 273:10475-10484(1998).
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Uniprot Description
GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding
Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; negative regulation of glycogen biosynthetic process; response to insulin stimulus
Research Articles on GRB10
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Product Notes
The GRB10 grb10 (Catalog #AAA9204511) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The GRB10 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GRB10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GRB10 grb10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRB10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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