Knockout Validation
(Knockout Validation: Lane 1: Wild-type HL60 cell lysate; Lane 2: GCA knockout HL60 cell lysate; Predicted MW: 24kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human GCA Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Grancalcin (GCA) Polyclonal Antibody | anti-GCA antibody
APC/CY7-Linked Polyclonal Antibody to Grancalcin (GCA)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type HL60 cell lysate; Lane 2: GCA knockout HL60 cell lysate; Predicted MW: 24kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human GCA Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type HL60 cell lysate; Lane 2: GCA knockout HL60 cell lysate; Predicted MW: 24kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human GCA Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Description
GCA: Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cytoplasm; plasma membrane
Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: proteolysis
Research Articles on GCA
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Product Notes
The GCA gca (Catalog #AAA2066181) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC/CY7-Linked Polyclonal Antibody to Grancalcin (GCA) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Grancalcin (GCA) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the GCA gca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Grancalcin (GCA), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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