Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using GRAH antibody.)
Rabbit anti-Human GRAH Polyclonal Antibody | anti-GRAH antibody
GRAH Antibody
Immunofluorescence: 1:100~1:500
Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using GRAH antibody.)
Western Blot (WB)
(Western blot analysis of extracts from K562 cells, using GRAH antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of A549 cells, using GRAH antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of A549 cells, using GRAH antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.
Protein type: Protease; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: serine-type endopeptidase activity
Biological Process: apoptosis; cytolysis; protein processing; immune response; proteolysis
Research Articles on GRAH
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Product Notes
The GRAH gzmh (Catalog #AAA9403441) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRAH Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GRAH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500~1:3000 Immunofluorescence: 1:100~1:500. Researchers should empirically determine the suitability of the GRAH gzmh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRAH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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