Rabbit anti-Human GPRC6A Polyclonal Antibody | anti-GPRC6A antibody

GPRC6A

Cat. Num. AAA556434

• Gene Names: GPRC6A; GPCR; bA86F4.3
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: GPRC6A; Polyclonal Antibody; anti-GPRC6A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Form/Format: Affinity Purified antibody; Liquid. PBS, 0.1% sodium azide
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPRC6A antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:1000-1:2000
• Immunogen: KLH conjugated synthetic peptide- N-terminal extracellular domain of human GPRC6A.
• Preparation and Storage: Long term: -70 degree C; Short term: 4 degree C. Repeated freeze/thaw cycles compromise the integrity of the antibody.

Testing Data

(GPRC6A of Human Skeletal Muscle(paraffin-embedded).)

Related Product Information for anti-GPRC6A antibody

GPR3, GPR6, and GPR12 make up a family of constitutively active G protein-coupled receptors (GPCRs) that share greater than 50% identity and 65% similarity at the amino acid level and are highly expressed in hippocampus and cortex, regions of the brain. They upregulate cyclic AMP Levels and Promotes Neurite Outgrowth.

GPR3 has been mapped to a chromosomal locus associated with increased risk for Alzheimer's disease. GPR3 is believed be a factor in accumulation of beta-amyloid (a protein believed to cause the disease).

NCBI and Uniprot Product Information

• NCBI GI #: 112807234
• NCBI GeneID: 222545
• NCBI Accession #: NP_683766.2
• NCBI GenBank Nucleotide #: NM_148963.2
• UniProt Accession #: Q5T6X5; Q6JK43; Q6JK44; Q8NGU8; Q8NHZ9; Q8TDT6
• Molecular Weight: 104,753 Da
• NCBI Official Full Name: G-protein coupled receptor family C group 6 member A
• NCBI Official Synonym Full Names: G protein-coupled receptor, family C, group 6, member A
• NCBI Official Symbol: GPRC6A
• NCBI Official Synonym Symbols: GPCR; bA86F4.3
• NCBI Protein Information: G-protein coupled receptor family C group 6 member A; hGPCR33; hGPRC6A; predicted with SOSUI analysis; G-protein coupled receptor GPCR33; seven transmembrane helix receptor
• UniProt Protein Name: G-protein coupled receptor family C group 6 member A
• Protein Family: G-protein coupled receptor family
• UniProt Gene Name: GPRC6A
• UniProt Synonym Gene Names: hGPRC6A; hGPCR33
• UniProt Entry Name: GPC6A_HUMAN

NCBI Description

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

Uniprot Description

GPRC6A: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 3; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; response to amino acid stimulus