Rabbit anti-Human, Mouse GPRASP1 Polyclonal Antibody | anti-GPRASP1 antibody

GPRASP1 Antibody

Cat. Num. AAA153455

• Gene Names: GPRASP1; GASP; GASP1; GASP-1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: GPRASP1 antibody is affinity chromatography purified via peptide column.
• Synonyms: GPRASP1; Polyclonal Antibody; GPRASP1 Antibody; G-protein coupled receptor-associated sorting protein 1; GASP; GASP-1; GASP1; G protein-coupled receptor associated sorting protein 1; anti-GPRASP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.
• Purity/Purification: GPRASP1 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1395

• Applicable Applications for anti-GPRASP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: GPRASP1 antibody can be used for detection of GPRASP1 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.
• Buffer: GPRASP1 antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: GPRASP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of SKI2W in mouse stomach tissue lysate with SKI2W antibody at 1 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SKI2W in human stomach tissue with SKI2W antibody at 5 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of SKI2W in human stomach tissue with SKI2W antibody at 20 μg/ml.)

Related Product Information for anti-GPRASP1 antibody

The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2). GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2). Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3).

NCBI and Uniprot Product Information

• NCBI GI #: 296080706
• NCBI GeneID: 9737
• NCBI Accession #: NP_001171656
• NCBI GenBank Nucleotide #: NM_001184727.1
• UniProt Accession #: Q5JY77; O43168; Q96LA1
• Molecular Weight: Predicted: 153 kDa; ; Observed: 150 kDa
• NCBI Official Full Name: G-protein coupled receptor-associated sorting protein 1
• NCBI Official Synonym Full Names: G protein-coupled receptor associated sorting protein 1
• NCBI Official Symbol: GPRASP1
• NCBI Official Synonym Symbols: GASP; GASP1; GASP-1
• NCBI Protein Information: G-protein coupled receptor-associated sorting protein 1
• UniProt Protein Name: G-protein coupled receptor-associated sorting protein 1
• Protein Family: G-protein coupled receptor-associated sorting protein
• UniProt Gene Name: GPRASP1
• UniProt Synonym Gene Names: GASP; KIAA0443; GASP-1
• UniProt Entry Name: GASP1_HUMAN

NCBI Description

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

Uniprot Description

GPRASP1: May modulate lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes. Belongs to the GPRASP family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: endosome to lysosome transport