Rabbit GPR39 Polyclonal Antibody | anti-GPR39 antibody

Rabbit Polyclonal to Human GPR39

Cat. Num. AAA243715

• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR39; Polyclonal Antibody; Rabbit Polyclonal to Human GPR39; Anti-GPR39 Antibody (C-Terminus) IHC-plus; G protein-coupled receptor 39; G-protein coupled receptor 39; Human GPR39; anti-GPR39 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR39. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CEP250 (65%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 453

• Applicable Applications for anti-GPR39 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (2 - 4 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from C-terminus of human GPR39. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Marmoset (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR39 antibody was raised against synthetic 20 amino acid peptide from C-terminus of human GPR39. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Marmoset (85%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR39 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR39 antibody

GPR39 is an Orphan-A GPCR with an unknown ligand. GPR39 is related to the growth hormone secretagogue receptor, which is a receptor for ghrelin. At least three mRNA variants of GPR39 have been reported.

Product Categories/Family for anti-GPR39 antibody

Family: GPCR; Subfamily: Orphan-A

NCBI and Uniprot Product Information

• NCBI GI #: 4504097
• NCBI GeneID: 2863
• NCBI Accession #: NP_001499.1
• NCBI GenBank Nucleotide #: NM_001508.2
• UniProt Accession #: O43194; Q08AS2; Q53R01; B2RC12; B6V9G4
• Molecular Weight: 51,329 Da
• NCBI Official Full Name: G-protein coupled receptor 39
• NCBI Official Synonym Full Names: G protein-coupled receptor 39
• NCBI Official Symbol: GPR39
• NCBI Protein Information: G-protein coupled receptor 39
• UniProt Protein Name: G-protein coupled receptor 39
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR39
• UniProt Entry Name: GPR39_HUMAN

Uniprot Description

GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q21-q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; metal ion binding

Biological Process: G-protein coupled receptor protein signaling pathway