Western Blot (WB)
(Western blot analysis of GPR30 expression in)
Rabbit GPR30 Polyclonal Antibody | anti-GPR30 antibody
GPR30 Antibody
Western Blot (WB)
(Western blot analysis of GPR30 expression in)
Western Blot (WB)
(Western blot analysis of GPR30 expression in)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
GPER1: Receptor for estrogen. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: axon; cytoplasm; cytoplasmic vesicle membrane; dendrite; dendritic shaft; early endosome; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; intracellular; keratin filament; mitochondrial membrane; nerve terminal; nuclear envelope; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; presynaptic active zone; presynaptic membrane; recycling endosome; trans-Golgi network
Molecular Function: chromatin binding; estrogen receptor activity; mineralocorticoid receptor activity; protein binding; steroid binding
Biological Process: apoptotic chromosome condensation; cytosolic calcium ion homeostasis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; generation of action potential; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of leukocyte activation; negative regulation of lipid biosynthetic process; negative regulation of protein kinase B signaling cascade; nuclear fragmentation during apoptosis; positive regulation of apoptosis; positive regulation of cAMP biosynthetic process; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of insulin secretion; positive regulation of MAPKKK cascade; positive regulation of neurogenesis; positive regulation of neurotransmitter secretion; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; steroid hormone mediated signaling; steroid hormone receptor signaling pathway
Research Articles on GPR30
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Product Notes
The GPR30 gper1 (Catalog #AAA9418315) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GPR30 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GPR30 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500-1:2000. Researchers should empirically determine the suitability of the GPR30 gper1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPR30, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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