Rabbit anti-Human, Rat GPR199 Polyclonal Antibody | anti-GPR199 antibody

GPR199 polyclonal antibody

Cat. Num. AAA3014889

• Gene Names: RAB34; RAH; RAB39
• Reactivity: Human, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR199; Polyclonal Antibody; GPR199 polyclonal antibody; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah; RAB34; RAB39; RAH; anti-GPR199 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: RAB34 polyclonal antibody detects endogenous levels of RAB34 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR199 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human RAB34
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -25 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of RAB34 polyclonal antibody at 1:500 dilutionLaneA: The muscle tissue lysate of Rat)

Related Product Information for anti-GPR199 antibody

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particular stage of a membrane transport pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 222144317
• NCBI GeneID: 83871
• NCBI Accession #: NP_001138414.1
• NCBI GenBank Nucleotide #: NM_001144942.1
• UniProt Accession #: Q9BZG1; Q5BJE6; Q8NCJ8; Q96AR4; B4E3A0; E9PEJ9
• Molecular Weight: 29,044 Da
• NCBI Official Full Name: ras-related protein Rab-34 isoform 4
• NCBI Official Synonym Full Names: RAB34, member RAS oncogene family
• NCBI Official Symbol: RAB34
• NCBI Official Synonym Symbols: RAH; RAB39
• NCBI Protein Information: ras-related protein Rab-34; ras-related protein Rah; ras-related protein Rab-39
• UniProt Protein Name: Ras-related protein Rab-34
• UniProt Gene Name: RAB34
• UniProt Synonym Gene Names: RAB39; RAH
• UniProt Entry Name: RAB34_HUMAN

NCBI Description

This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]

Uniprot Description

RAB34: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region. Belongs to the small GTPase superfamily. Rab family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, Rab; Nucleolus

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: Golgi apparatus; Golgi cisterna; phagocytic vesicle membrane; Golgi stack; perinuclear region of cytoplasm; phagocytic vesicle; vesicle

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Ral GTPase binding

Biological Process: antigen processing and presentation; lysosome localization; metabolic process; Golgi to plasma membrane protein transport; Rab protein signal transduction