Rabbit anti-Human GPR188 Polyclonal Antibody | anti-GPR188 antibody

GPR188 polyclonal antibody

Cat. Num. AAA3014878

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR188; Polyclonal Antibody; GPR188 polyclonal antibody; ABCC13; anti-GPR188 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ABCC13 polyclonal antibody detects endogenous levels of ABCC13 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR188 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human ABCC13
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -25 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of ABCC13 polyclonal antibody at 1:500 dilutionLaneA: HT29 whole cell lysate)

Related Product Information for anti-GPR188 antibody

The S-100 protein family consists of a group of calcium-binding proteins that are exclusively expressed in vertebrates and exhibit cell and tissue-specific expression. The expression levels of its members differ in various pathological conditions. The extracellular functions of the S-100 family may include the ability to enhance neurite outgrowth, involvement in inflammation and motility of tumor cells. S-100Z (S100 calcium-binding protein Z) is a 99 amino acid protein that shares 57% and 52% sequence identity with S-100A1 and S-100P, respectively. A dimeric, predominantly alpha-helical protein, S-100Z contains two EF-hand domains capable of binding calcium ions. Binding of calcium results in conformational changes and exposure of hydrophobic surfaces on the protein. S-100Z interacts with S-100P, and demonstrates highest level of expression in spleen and leukocytes. The S-100Z gene is conserved in chimpanzee, bovine, mouse, rat, chicken and zebrafish, and maps to human chromosome 5q13.3.

NCBI and Uniprot Product Information

• NCBI GI #: 21541961
• UniProt Accession #: Q9NSE7; Q8N6A4; Q8N6A5
• Molecular Weight: 30,831 Da
• NCBI Official Full Name: Putative ATP-binding cassette sub-family C member 13
• UniProt Protein Name: Putative ATP-binding cassette sub-family C member 13
• UniProt Gene Name: ABCC13
• UniProt Synonym Gene Names: C21orf73; PRED6
• UniProt Entry Name: ABCCD_HUMAN

Uniprot Description

ABCC13: a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Protein type: Transporter; Membrane protein, integral; Hydrolase; Transporter, ABC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 21q11.2

Cellular Component: integral to membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: transmembrane transport