Rabbit GPR178 Polyclonal Antibody | anti-GPR178 antibody

GPR178 polyclonal antibody

Cat. Num. AAA3014868

• Gene Names: KCNF1; IK8; kH1; KCNF; KV5.1
• Reactivity: Human, Rat, Mouse
• Applications: Western Blot
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR178; Polyclonal Antibody; GPR178 polyclonal antibody; Potassium voltage-gated channel subfamily F member 1; Voltage-gated potassium channel subunit Kv5.1; Kh1; KCNF1; anti-GPR178 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Kv5.1 polyclonal antibody detects endogenous levels of Kv5.1 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR178 antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human Kv51
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -25 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of Kv5.1 polyclonal antibody at 1:500 dilutionLaneA: COS-7 whole cell lysateLaneB: Panc1 whole cell lysateLaneC: The heart tissue lysate of MouseLaneD: The heart tissue lysate of Rat)

Related Product Information for anti-GPR178 antibody

KCNF1 (potassium voltage-gated channel subfamily F member 1) is a multipass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas.

NCBI and Uniprot Product Information

• NCBI GI #: 20070166
• NCBI GeneID: 3754
• NCBI Accession #: NP_002227.2
• NCBI GenBank Nucleotide #: NM_002236.4
• UniProt Accession #: Q9H3M0; O43527; Q585L3
• Molecular Weight: 55,584 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily F member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, subfamily F, member 1
• NCBI Official Symbol: KCNF1
• NCBI Official Synonym Symbols: IK8; kH1; KCNF; KV5.1
• NCBI Protein Information: potassium voltage-gated channel subfamily F member 1; potassium channel KH1; potassium channel Kv5.1; voltage-gated potassium channel subunit Kv5.1
• UniProt Protein Name: Potassium voltage-gated channel subfamily F member 1
• UniProt Gene Name: KCNF1
• UniProt Entry Name: KCNF1_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv5.1: Putative voltage-gated potassium channel. Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: potassium channel activity; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization