Rabbit anti-Human, Rat GPR173 Polyclonal Antibody | anti-GPR173 antibody

GPR173 polyclonal antibody

Cat. Num. AAA3014863

• Gene Names: PVRL4; LNIR; PRR4; EDSS1; nectin-4
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR173; Polyclonal Antibody; GPR173 polyclonal antibody; Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; NECTIN4; LNIR; PRR4; PVRL4; anti-GPR173 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Nectin 4 polyclonal antibody detects endogenous levels of Nectin 4 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR173 antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human Nectin 4
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -21 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of Nectin 4 polyclonal antibody at 1:500 dilutionLaneA: Hela whole cell lysateLaneB: MCF-7 whole cell lysateLaneC: PC12 whole cell lysate)

Related Product Information for anti-GPR173 antibody

Nectin-4/Poliovirus Receptor-Like 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions. The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus and to neighboring cells through trans heterophilic interactions with Nectin-1. Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta. Research studies have demostrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas, breast, lung, and ovary. Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel test and therapeutic target for a variety of human tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 222136611
• NCBI GeneID: 81607
• NCBI Accession #: NP_112178.2
• NCBI GenBank Nucleotide #: NM_030916.2
• UniProt Accession #: Q96NY8; Q96K15
• Molecular Weight: 55,454 Da
• NCBI Official Full Name: poliovirus receptor-related protein 4
• NCBI Official Synonym Full Names: poliovirus receptor-related 4
• NCBI Official Symbol: PVRL4
• NCBI Official Synonym Symbols: LNIR; PRR4; EDSS1; nectin-4
• NCBI Protein Information: poliovirus receptor-related protein 4; nectin 4; Ig superfamily receptor LNIR
• UniProt Protein Name: Poliovirus receptor-related protein 4
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: PVRL4
• UniProt Synonym Gene Names: LNIR; PRR4
• UniProt Entry Name: PVRL4_HUMAN

NCBI Description

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

Uniprot Description

nectin 4: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells. Defects in PVRL4 are the cause of ectodermal dysplasia- syndactyly syndrome type 1 (EDSS1). EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. Belongs to the nectin family.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: adherens junction; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell adhesion

Disease: Ectodermal Dysplasia-syndactyly Syndrome 1