Rabbit GPR161 Polyclonal Antibody | anti-GPR161 antibody

Rabbit Polyclonal to Human GPR161

Cat. Num. AAA242731

• Gene Names: GPR161; RE2
• Reactivity: Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Pig, Rabbit; Predicted Reactivity: Mouse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR161; Polyclonal Antibody; Rabbit Polyclonal to Human GPR161; Anti-GPR161 Antibody (C-Terminus) IHC-plus; G-protein coupled receptor 161; G protein-coupled receptor 161; G-protein coupled receptor RE2; RE2; Human GPR161; anti-GPR161 antibody

• Host: Rabbit
• Reactivity: Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Pig, Rabbit; Predicted Reactivity: Mouse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR161. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 529

• Applicable Applications for anti-GPR161 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from C-terminus of human GPR161. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%); Mouse, Opossum (95%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR161 antibody was raised against synthetic 19 amino acid peptide from C-terminus of human GPR161. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%); Mouse, Opossum (95%); Bat, Turkey, Chicken (89%); Platypus, Stickleback, Pufferfish (84%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR161 antibody

GPR161/RE2 is an Orphan-U GPCR with an unknown ligand. RE2 is a member of the rhodopsin family of G protein-coupled receptors and may aid in the regulation of aggression and appetite.

Product Categories/Family for anti-GPR161 antibody

Family: GPCR; Subfamily: Orphan-U

NCBI and Uniprot Product Information

• NCBI GI #: 24476016
• NCBI GeneID: 23432
• NCBI Accession #: NP_722561.1
• NCBI GenBank Nucleotide #: NM_153832.2
• UniProt Accession #: Q8N6U8; O75963; Q5TGK0; Q5TGK1; Q5TGK2; B3KV34; B7Z5D7; B7Z5E8; B7Z5Z6; F5GXD6; F5H6J7
• Molecular Weight: 60,659 Da
• NCBI Official Full Name: G-protein coupled receptor 161 isoform 2
• NCBI Official Synonym Full Names: G protein-coupled receptor 161
• NCBI Official Symbol: GPR161
• NCBI Official Synonym Symbols: RE2
• NCBI Protein Information: G-protein coupled receptor 161; G-protein coupled receptor RE2
• UniProt Protein Name: G-protein coupled receptor 161
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR161
• UniProt Entry Name: GP161_HUMAN

NCBI Description

Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]

Uniprot Description

GPR161: Orphan receptor. Plays a role in neurulation and lens development. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: recycling endosome; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; multicellular organismal development; positive regulation of cAMP biosynthetic process