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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human colon cancer using MBS1493140 at dilution 1:100)

Rabbit anti-Human GOSR1 Polyclonal Antibody | anti-GOSR1 antibody

GOSR1 Antibody

Gene Names
GOSR1; P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
GOSR1; Polyclonal Antibody; GOSR1 Antibody; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28; GS28; anti-GOSR1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
185
Applicable Applications for anti-GOSR1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Recommended dilution: IHC:1:20-1:200
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Golgi SNAP receptor complex member 1 protein (1-115aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15270 / sc-15271 / sc-30096
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1493140 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human colon cancer using MBS1493140 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS1493140 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human kidney using MBS1493140 at dilution 1:100)
Related Product Information for anti-GOSR1 antibody
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
21,214 Da
NCBI Official Full Name
Golgi SNAP receptor complex member 1 isoform 3
NCBI Official Synonym Full Names
golgi SNAP receptor complex member 1
NCBI Official Symbol
GOSR1
NCBI Official Synonym Symbols
P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
NCBI Protein Information
Golgi SNAP receptor complex member 1
UniProt Protein Name
Golgi SNAP receptor complex member 1
UniProt Gene Name
GOSR1
UniProt Synonym Gene Names
GS28; GOS-28
UniProt Entry Name
GOSR1_HUMAN

NCBI Description

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GOSR1: a single-pass type IV Golgi membrane protein. Enriched on vesicular components at the terminal rims of the Golgi. Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR2, STX5, GABARAPL2 and YKT6.

Protein type: Membrane protein, integral; Vesicle; Autophagy

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: cis-Golgi network; Golgi apparatus; Golgi medial cisterna; Golgi membrane; integral to membrane; membrane; SNARE complex

Molecular Function: SNAP receptor activity; SNARE binding

Biological Process: cellular protein metabolic process; ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein transport; regulation of vesicle targeting, to, from or within Golgi; retrograde transport, endosome to Golgi; vesicle fusion

Research Articles on GOSR1

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Product Notes

The GOSR1 gosr1 (Catalog #AAA1493140) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GOSR1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GOSR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the GOSR1 gosr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GOSR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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