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Western Blot (WB) (GNRH1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GNRH1 antibody detected the GNRH1 protein (arrow).)

Rabbit anti-Human Gonadotropin-releasing Hormone Polyclonal Antibody | anti-GRH antibody

Gonadotropin-releasing Hormone, NT (GnRH, GRH, Gonadotrophin Releasing Hormone 1, GNRH1, GnRH-I, Gonadoliberin I, Gonadoliberin-1, Gonadorelin, Luliberin I, Luteinizing Hormorne Releasing Hormone, LHRH, LH-RH I, LNRH, Luteinizing Releasing Hormone, Progon

Gene Names
GNRH1; GRH; GNRH; LHRH; LNRH
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Purified by Ammonium Sulfate Precipitation.
Synonyms
Gonadotropin-releasing Hormone; Polyclonal Antibody; NT (GnRH; GRH; Gonadotrophin Releasing Hormone 1; GNRH1; GnRH-I; Gonadoliberin I; Gonadoliberin-1; Gonadorelin; Luliberin I; Luteinizing Hormorne Releasing Hormone; LHRH; LH-RH I; LNRH; Luteinizing Releasing Hormone; Progon; Gonadotropin-releasing Hormone I; Gonadotropin-releasing Hormone 1 (Luteinizing-releasing Hormone); Luteinizing Hormone-releasing Hormone I; anti-GRH antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human GNRH1.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Sequence Length
96
Applicable Applications for anti-GRH antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
IHC: 1:10-1:50
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
Synthetic peptide selected from the N-terminal region of human GNRH1 (KLH).
Conjugate
HRP
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Western Blot (WB)

(GNRH1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GNRH1 antibody detected the GNRH1 protein (arrow).)

Western Blot (WB) (GNRH1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GNRH1 antibody detected the GNRH1 protein (arrow).)

Immunohistochemistry (IHC)

(GNRH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GNRH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (GNRH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GNRH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Product Categories/Family for anti-GRH antibody
References
1. Hong, I.S., J. Clin. Endocrinol. Metab. 93(8), 3179-3185 (2008). 2. Baroncini, M., J. Neuroendocrinol. 19(9), 691-702 (2007). 3. Nikolics, K., Nature 316(6028), 511-517 (1985).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10.38
NCBI Official Full Name
progonadoliberin-1 isoform 1
NCBI Official Synonym Full Names
gonadotropin releasing hormone 1
NCBI Official Symbol
GNRH1
NCBI Official Synonym Symbols
GRH; GNRH; LHRH; LNRH
NCBI Protein Information
progonadoliberin-1
UniProt Protein Name
Progonadoliberin-1
UniProt Gene Name
GNRH1
UniProt Synonym Gene Names
GNRH; GRH; LHRH; GnRH-I; LH-RH I
UniProt Entry Name
GON1_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Uniprot Description

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Research Articles on GRH

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Product Notes

The GRH gnrh1 (Catalog #AAA6478730) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Gonadotropin-releasing Hormone, NT (GnRH, GRH, Gonadotrophin Releasing Hormone 1, GNRH1, GnRH-I, Gonadoliberin I, Gonadoliberin-1, Gonadorelin, Luliberin I, Luteinizing Hormorne Releasing Hormone, LHRH, LH-RH I, LNRH, Luteinizing Releasing Hormone, Progon reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Gonadotropin-releasing Hormone can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:10-1:50 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the GRH gnrh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Gonadotropin-releasing Hormone, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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