Rabbit GNAZ Polyclonal Antibody | anti-GNAZ antibody

GNAZ (A12) Polyclonal Antibody

Cat. Num. AAA3003289

• Gene Names: GNAZ; gz-alpha
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GNAZ; Polyclonal Antibody; GNAZ (A12) Polyclonal Antibody; Guanine nucleotide-binding protein G(z) subunit alpha; G(x) alpha chain; Gz-alpha; Gzalpha; anti-GNAZ antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GNAZ (A12) polyclonal antibody detects endogenous levels of GNAZ protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 355

• Applicable Applications for anti-GNAZ antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to the N-terminus of Human GNAZ.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of GNAZ (A12) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.)

Related Product Information for anti-GNAZ antibody

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. G protein z alpha, encoded by the GNAZ gene, is enriched in neural tissue and differs in sequence from other G alpha subunits. Alpha Subunits are encoded in 15 genes and several transcripts are alternatively spliced. Receptors may discriminate between splice variants; whether splice variants are functionally different in regulating effectors is not known. All alpha subunits appear to be palmitoylated near the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 121005
• NCBI GeneID: 2781
• UniProt Accession #: P19086
• Molecular Weight: ~ 41kDa
• NCBI Official Full Name: Guanine nucleotide-binding protein G(z) subunit alpha
• NCBI Official Synonym Full Names: G protein subunit alpha z
• NCBI Official Symbol: GNAZ
• NCBI Official Synonym Symbols: gz-alpha
• NCBI Protein Information: guanine nucleotide-binding protein G(z) subunit alpha
• UniProt Protein Name: Guanine nucleotide-binding protein G(z) subunit alpha
• UniProt Gene Name: GNAZ
• UniProt Entry Name: GNAZ_HUMAN

NCBI Description

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Uniprot Description

G-alpha(z): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: Nuclear envelope; Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: endoplasmic reticulum; plasma membrane; heterotrimeric G-protein complex; nuclear envelope; cytosol

Molecular Function: GTPase activity; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; receptor signaling protein activity; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway