Western Blot (WB)
(Western Blot analysis of GNAS expression in transfected 293T cell line by GNAS polyclonal antibody. Lane 1: GNAS transfected lysate (45.7kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human GNAS Polyclonal Antibody | anti-GNAS antibody
GNAS (Guanine Nucleotide Binding Protein G(s) Subunit alpha Isoforms XLas, GNAS1, GPSA, GSA, Adenylate Cyclase Stimulating G alpha Protein, AHO, C20orf45, Extra Large alphas Protein, XLalphas, GSP, MGC33735, NESP, PHP1A, PHP1B, PHP1C, POH) (AP)
Western Blot (WB)
(Western Blot analysis of GNAS expression in transfected 293T cell line by GNAS polyclonal antibody. Lane 1: GNAS transfected lysate (45.7kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of GNAS expression in transfected 293T cell line by GNAS polyclonal antibody. Lane 1: GNAS transfected lysate (45.7kD). Lane 2: Non-transfected lysate.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between GNAS and ADCY2. HeLa cells were stained with GNAS rabbit purified polyclonal 1:1200 and ADCY2 mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between GNAS and ADCY2. HeLa cells were stained with GNAS rabbit purified polyclonal 1:1200 and ADCY2 mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
NCBI and Uniprot Product Information
NCBI Description
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Research Articles on GNAS
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Product Notes
The GNAS (Catalog #AAA6380033) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GNAS (Guanine Nucleotide Binding Protein G(s) Subunit alpha Isoforms XLas, GNAS1, GPSA, GSA, Adenylate Cyclase Stimulating G alpha Protein, AHO, C20orf45, Extra Large alphas Protein, XLalphas, GSP, MGC33735, NESP, PHP1A, PHP1B, PHP1C, POH) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GNAS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the GNAS for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GNAS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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