Rabbit anti-Human Glycogen Phosphorylase, Brain Form Polyclonal Antibody | anti-PYGB antibody

Glycogen Phosphorylase, Brain Form (PYGB, EC 2.4.1.1, MGC9213)

Cat. Num. AAA611408

• Gene Names: PYGB; MGC9213
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Glycogen Phosphorylase; Brain Form; Polyclonal Antibody; Brain Form (PYGB; EC 2.4.1.1; MGC9213); Anti -Glycogen Phosphorylase; anti-PYGB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes Human Glycogen Phosphorylase, Brain Form (PYGB). Species Crossreactivity: Human.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-PYGB antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Paraffin sections): 10ug/ml
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: internal domain of human
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(Figure 1. Brain: Formalin-Fixed Paraffin-Embedded (FFPE))

Product Categories/Family for anti-PYGB antibody

Antibodies; Abs to Enzymes; Phosphorylase

NCBI and Uniprot Product Information

• NCBI GI #: 21361370
• NCBI GeneID: 5834
• NCBI Accession #: NP_002853.2
• NCBI GenBank Nucleotide #: NM_002862.3
• UniProt Accession #: P11216; Q96AK1; Q9NPX8; Q59GM9; Q5JWL9; Q8TDG6
• Molecular Weight: 96,696 Da
• NCBI Official Full Name: glycogen phosphorylase, brain form
• NCBI Official Synonym Full Names: phosphorylase, glycogen; brain
• NCBI Official Symbol: PYGB
• NCBI Official Synonym Symbols: MGC9213
• NCBI Protein Information: glycogen phosphorylase, brain form; OTTHUMP00000030488; glycogen phosphorylase B
• UniProt Protein Name: Glycogen phosphorylase, brain form
• Protein Family: Glycogen phosphorylase
• UniProt Gene Name: PYGB
• UniProt Entry Name: PYGB_HUMAN

NCBI Description

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq]

Uniprot Description

PYGB: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family.

Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Kinase, other; Phosphorylase; Transferase

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: membrane; cytoplasm

Molecular Function: glycogen phosphorylase activity; pyridoxal phosphate binding

Biological Process: glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis