Rabbit anti-Mouse Glutathione S Transferase Pi (GSTp) Polyclonal Antibody | anti-GSTp antibody

Biotin-Linked Antibody to Glutathione S Transferase Pi (GSTp)

Cat. Num. AAA2006714

• Gene Names: GSTP1; PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
• Reactivity: Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Affinity Chromatography
• Synonyms: Glutathione S Transferase Pi (GSTp); Polyclonal Antibody; Biotin-Linked Antibody to Glutathione S Transferase Pi (GSTp); anti-GSTp antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against GSTp conjugated to biotin. It has been selected for its ability to recognize GSTp in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 210

• Applicable Applications for anti-GSTp antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: Western blotting: 1:100-400; Immunocytochemistry in formalin fixed cells: 1:100-500; Immunohistochemistry in formalin fixed frozen section: 1:100-500; Immunohistochemistry in paraffin section: 1:50-200; Enzyme-linked Immunosorbent Assay: 1:100-200
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Product Categories/Family for anti-GSTp antibody

Biotin Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 32187525
• NCBI GeneID: 2950
• UniProt Accession #: P09211; O00460; Q15690; Q5TZY3
• Molecular Weight: 23,356 Da
• NCBI Official Full Name: glutathione S-transferase pi
• NCBI Official Synonym Full Names: glutathione S-transferase pi 1
• NCBI Official Symbol: GSTP1
• NCBI Official Synonym Symbols: PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
• NCBI Protein Information: glutathione S-transferase P; GSTP1-1; GST class-pi; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III
• UniProt Protein Name: Glutathione S-transferase P
• UniProt Gene Name: GSTP1
• UniProt Synonym Gene Names: FAEES3; GST3
• UniProt Entry Name: GSTP1_HUMAN

NCBI Description

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family.

Protein type: EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; mitochondrion; cytoplasm; plasma membrane; intracellular; cytosol; nucleus; vesicle

Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity

Biological Process: negative regulation of MAP kinase activity; negative regulation of JNK activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of tumor necrosis factor production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta production; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; response to reactive oxygen species; negative regulation of biosynthetic process; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; xenobiotic metabolic process; positive regulation of superoxide release; negative regulation of protein kinase activity; negative regulation of apoptosis