Rabbit Glucose Regulated Protein 78 Polyclonal Antibody | anti-BiP/grp78 antibody

Glucose Regulated Protein 78 (Hspa5, Heat Shock Protein 5, 78kD, 78kD Glucose-Regulated Protein precursor, AL022860, AU019543, Bip, BiP, D2Wsu141e, D2Wsu17e, Grp78, GRP 78, Heat shock 70kD protein 5, Heat Shock 70kD Protein 5, Hsce70, Immunoglobulin heavy

Cat. Num. AAA621971

• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry
• Purity: Serum
• Synonyms: Glucose Regulated Protein 78; Polyclonal Antibody; Glucose Regulated Protein 78 (Hspa5; Heat Shock Protein 5; 78kD; 78kD Glucose-Regulated Protein precursor; AL022860; AU019543; Bip; BiP; D2Wsu141e; D2Wsu17e; Grp78; GRP 78; Heat shock 70kD protein 5; Heat Shock 70kD Protein 5; Hsce70; Immunoglobulin heavy; Anti -Glucose Regulated Protein 78 (Hspa5; anti-BiP/grp78 antibody

• Host: Rabbit
• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat Glucose Regulated Protein 78. Species Crossreactivity: human, mouse, bovine, fungus (Cryphonectria |parasitica), hamster, monkey, rabbit, canine and Xenopus
• Purity/Purification: Serum
• Form/Format: Supplied as a liquid.

• Applicable Applications for anti-BiP/grp78 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorecence (IF), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot:1:2000 (ECL) 10ug of rat tissue lysate; Immunofluorescence/Immunocytochemistry: 1:100.; Optimal dilutions to be determined by the researcher.
• Grade: Serum
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-BiP/grp78 antibody

GRP78 is a ubiquitously expressed, 78kD glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimer’s patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs.

Product Categories/Family for anti-BiP/grp78 antibody

Antibodies; Abs to Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 170384
• NCBI GeneID: 543957
• UniProt Accession #: P49118
• NCBI Official Full Name: glucose-regulated protein 78
• NCBI Official Symbol: BiP/grp78
• NCBI Protein Information: glucose-regulated protein 78
• UniProt Protein Name: Luminal-binding protein
• UniProt Entry Name: BIP_SOLLC

Uniprot Description

Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular location: Endoplasmic reticulum lumen.

Sequence similarities: Belongs to the heat shock protein 70 family.