Western Blot (WB)
(Western Blot analysis of GKN1 in Human stomach tissue lysate using GKN1 Rabbit pAb at dilution 1/250)
Rabbit anti-Human GKN1 Polyclonal Antibody | anti-GKN1 antibody
GKN1 Rabbit pAb
Gene Names
GKN1; FOV; CA11; AMP18; BRICD1; foveolin
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
GKN1; Polyclonal Antibody; GKN1 Rabbit pAb; gastrokine 1; FOV; CA11; AMP18; BRICD1; foveolin; anti-GKN1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-GKN1 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:500-1:2000
IHC-P: 1:25-1:100
IHC-P: 1:25-1:100
Immunogen
Synthetic peptide of human GKN1
Conjugation
Unconjugated
Modification
Unmodified
Preparation and Storage
Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.
Western Blot (WB)
(Western Blot analysis of GKN1 in Human stomach tissue lysate using GKN1 Rabbit pAb at dilution 1/250)
Western Blot (WB)
(Western Blot analysis of GKN1 in Human stomach tissue lysate using GKN1 Rabbit pAb at dilution 1/250)
Immunohistochemistry (IHC)
(Immunohistochemistry of GKN1 in paraffin-embedded Human colorectal cancer tissue using GKN1 Rabbit pAb at dilution 1/30. Predicted cell location: Secreted)
Immunohistochemistry (IHC)
(Immunohistochemistry of GKN1 in paraffin-embedded Human colorectal cancer tissue using GKN1 Rabbit pAb at dilution 1/30. Predicted cell location: Secreted)
Related Product Information for anti-GKN1 antibody
Gastrokine 1 (GKN1), a stomach-speci?c protein also known as 18 kDa antrum mucosa protein (AMP-18) or foveolin, belongs to the gastrokine family of gastric mucus cell-secreted proteins. The human GKN1 gene has been localized in a region of chromosome 2p13 of about 6 kb and contains 6 exons. GKN1 is expressed only in normal human stomach, but is absent from gastric adenocarcinomas, gastro-esophageal adenocarcinoma cell lines, and other normal and tumor gastro-intestinal tissues. GKN1may play an important role in normal gastric function and may be a gastric tumour suppressor.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,999 Da
NCBI Official Full Name
gastrokine-1
NCBI Official Synonym Full Names
gastrokine 1
NCBI Official Symbol
GKN1
NCBI Official Synonym Symbols
FOV; CA11; AMP18; BRICD1; foveolin
NCBI Protein Information
gastrokine-1; AMP-18; BRICHOS domain containing 1; 18 kDa antrum mucosa protein
UniProt Protein Name
Gastrokine-1
Protein Family
UniProt Gene Name
GKN1
UniProt Synonym Gene Names
AMP18; CA11; AMP-18
UniProt Entry Name
GKN1_HUMAN
NCBI Description
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
Uniprot Description
GKN1: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Belongs to the gastrokine family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: extracellular region; secretory granule
Molecular Function: growth factor activity
Biological Process: positive regulation of cell division; positive regulation of cell proliferation; digestion
Research Articles on GKN1
Similar Products
Product Notes
The GKN1 gkn1 (Catalog #AAA4759700) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GKN1 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GKN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the GKN1 gkn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GKN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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