Rabbit anti-Human GH2 Polyclonal Antibody | anti-GH2 antibody

GH2, NT (GH2, Growth hormone variant, Growth hormone 2, Placenta-specific growth hormone) (Biotin)

Cat. Num. AAA6302195

• Gene Names: GH2; GHL; GHV; GH-V; hGH-V
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GH2; Polyclonal Antibody; NT (GH2; Growth hormone variant; Growth hormone 2; Placenta-specific growth hormone) (Biotin); Placenta-specific growth hormone; anti-GH2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-GH2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human GH2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GH2 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GH2 antibody detected the GH2 protein (arrow).)

Related Product Information for anti-GH2 antibody

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq].

Product Categories/Family for anti-GH2 antibody

Antibodies; Hormones; Steroids

References

McElholm, A.R., et al. Gastroenterology 139(1):204-212(2010). de Jesus Romero-Prado, M.M., et al. Gene 452(1):7-15(2010). Christiansen, M. Prenat. Diagn. 29(13):1249-1255(2009). Zeck, W., et al. Pediatr. Res. 63(4):353-357(2008). Mittal, P., et al. J. Matern. Fetal. Neonatal. Med. 20(9):651-659(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 4503991
• NCBI GeneID: 2689
• NCBI Accession #: NP_002050.1
• NCBI GenBank Nucleotide #: NM_002059.4
• UniProt Accession #: P01242; O14643; O14644; P09587; B1A4H5; B1A4H7
• Molecular Weight: 27,101 Da
• NCBI Official Full Name: growth hormone variant isoform 1
• NCBI Official Synonym Full Names: growth hormone 2
• NCBI Official Symbol: GH2
• NCBI Official Synonym Symbols: GHL; GHV; GH-V; hGH-V
• NCBI Protein Information: growth hormone variant; placenta-specific growth hormone; placental-specific growth hormone
• UniProt Protein Name: Growth hormone variant
• Protein Family: Growth hormone
• UniProt Gene Name: GH2
• UniProt Synonym Gene Names: GH-V
• UniProt Entry Name: SOM2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular region

Molecular Function: hormone activity