Western Blot (WB)
(GDI2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the GDI2 antibody detected the GDI2 protein (arrow).)
Rabbit anti-Human GDI2 Polyclonal Antibody | anti-GDI2 antibody
GDI2 Antibody (Center)
Western Blot (WB)
(GDI2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the GDI2 antibody detected the GDI2 protein (arrow).)
Western Blot (WB)
(GDI2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the GDI2 antibody detected the GDI2 protein (arrow).)
Immunohistochemistry (IHC)
(GDI2 Antibody (Center) (MBS9202411)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GDI2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(GDI2 Antibody (Center) (MBS9202411)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GDI2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
GDP-GTP exchange reaction of members of the rab family, small
GTP-binding proteins of the ras superfamily, that are involved in
vesicular trafficking of molecules between cellular organelles.
GDIs slow the rate of dissociation of GDP from rab proteins and
release GDP from membrane-bound rabs. GDI2 is ubiquitously
expressed. The GDI2 gene contains many repetitive elements
indicating that it may be prone to inversion/deletion
rearrangements. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.
Sun, Z.L., et al. Biochim. Biophys. Acta 1774(6):764-771(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Shin, B.K., et al. J. Biol. Chem. 278(9):7607-7616(2003)
NCBI and Uniprot Product Information
NCBI Description
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
GDI2: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: Golgi apparatus; focal adhesion; membrane; cytoplasm; cytosol; vesicle
Molecular Function: small GTPase binding; protein binding; Rab GDP-dissociation inhibitor activity
Biological Process: vesicle-mediated transport; protein transport; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; signal transduction
Research Articles on GDI2
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Product Notes
The GDI2 gdi2 (Catalog #AAA9202411) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 135-164. The GDI2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GDI2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the GDI2 gdi2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDI2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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