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Immunohistochemistry (IHC) (Anti-GDI2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Rabbit anti-Human GDI2 Polyclonal Antibody | anti-GDI2 antibody

Rabbit Polyclonal to Human GDI2

Gene Names
GDI2; RABGDIB; HEL-S-46e
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity Purified
Synonyms
GDI2; Polyclonal Antibody; Rabbit Polyclonal to Human GDI2; Anti-GDI2 Antibody IHC-plus; GDP dissociation inhibitor 2; GDI-2; Rab GDI beta; RABGDIB; Human GDI2; anti-GDI2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human Rho GDI2. Predicted cross-reactivity based on amino acid sequence homology: mouse (90%), rat (89%), bovine (93%).
Purity/Purification
Immunoaffinity Purified
Form/Format
0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
Concentration
1 mg/ml (varies by lot)
Sequence Length
445
Applicable Applications for anti-GDI2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes
IHC-P (10 ug/ml), WB (1:500 - 1:3000)
Target Species
Human
Immunogen Description
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 197 of Human Rho GDI2.
Immunogen Type
Recombinant protein
Immunogen
GDI2 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 197 of Human Rho GDI2.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-GDI2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC) (Anti-GDI2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-GDI2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC) (Anti-GDI2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Sample(30g whole cell lysate). A: 293T. B: A431. C: H1299. D: HeLa S3. E: Hep G2. 12% SDS PAGE. GDI2 antibody diluted at 1:1000)

Western Blot (WB) (Sample(30g whole cell lysate). A: 293T. B: A431. C: H1299. D: HeLa S3. E: Hep G2. 12% SDS PAGE. GDI2 antibody diluted at 1:1000)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,619 Da
NCBI Official Full Name
rab GDP dissociation inhibitor beta isoform 1
NCBI Official Synonym Full Names
GDP dissociation inhibitor 2
NCBI Official Symbol
GDI2
NCBI Official Synonym Symbols
RABGDIB; HEL-S-46e
NCBI Protein Information
rab GDP dissociation inhibitor beta; GDI-2; rab GDI beta; rab GDP-dissociation inhibitor, beta; guanosine diphosphate dissociation inhibitor 2; epididymis secretory sperm binding protein Li 46e
UniProt Protein Name
Rab GDP dissociation inhibitor beta
UniProt Gene Name
GDI2
UniProt Synonym Gene Names
RABGDIB; Rab GDI beta; GDI-2
UniProt Entry Name
GDIB_HUMAN

NCBI Description

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

GDI2: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: Golgi apparatus; focal adhesion; membrane; cytoplasm; cytosol; vesicle

Molecular Function: small GTPase binding; protein binding; Rab GDP-dissociation inhibitor activity

Biological Process: vesicle-mediated transport; protein transport; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; signal transduction

Research Articles on GDI2

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Product Notes

The GDI2 gdi2 (Catalog #AAA242757) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human GDI2 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GDI2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (10 ug/ml), WB (1:500 - 1:3000). Researchers should empirically determine the suitability of the GDI2 gdi2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDI2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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