Goat GDF2/BMP9 Polyclonal Antibody | anti-GDF2 antibody
Goat anti-GDF2/BMP9 Antibody
Western Blot: Preliminary experiments gave an approx 27kDa band in Human Bone Marrow, Liver, and Brain (cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 47.3kDa according to NP_057288.1. The 27kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]
Uniprot Description
GDF2: Could be involved in bone formation. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.22
Cellular Component: cell; extracellular space
Molecular Function: cytokine activity; growth factor activity; protein binding; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; cartilage development; cell development; cellular iron ion homeostasis; growth; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of DNA replication; negative regulation of endothelial cell proliferation; ossification; osteoblast differentiation; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; vasculogenesis
Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5
Research Articles on GDF2
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Product Notes
The GDF2 gdf2 (Catalog #AAA422057) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-GDF2/BMP9 Antibody reacts with Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's GDF2/BMP9 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave an approx 27kDa band in Human Bone Marrow, Liver, and Brain (cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 47.3kDa according to NP_057288.1. The 27kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the GDF2 gdf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KRWVRSDSTK SK. It is sometimes possible for the material contained within the vial of "GDF2/BMP9, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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