Western Blot (WB)
(Western Blot (WB) analysis of GDA polyclonal antibody)
Rabbit GDA Polyclonal Antibody | anti-GDA antibody
GDA Polyclonal Antibody
Gene Names
GDA; GAH; CYPIN; GUANASE; NEDASIN
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
GDA; Polyclonal Antibody; GDA Polyclonal Antibody; CYPIN; Cytoplasmic PSD95 interactor; D10S105E; GAH; GUAD_HUMAN; Guanase; Guanine aminase; Guanine aminohydrolase; Guanine deaminase; MGC9982; NEDASIN; p51-nedasin; SLC25A16; anti-GDA antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
GDA polyclonal antibody detects endogenous levels of GDA protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
471
Applicable Applications for anti-GDA antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IF: 1:50-1:100
IF: 1:50-1:100
Immunogen
Recombinant full length Human GDA.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of GDA polyclonal antibody)
Western Blot (WB)
(Western Blot (WB) analysis of GDA polyclonal antibody)
Related Product Information for anti-GDA antibody
The assembly of neurotransmitter receptors and associated signal transduction machinery at synaptic sites involves postsynaptic density 95 (PSD-95) and related membrane-associated guanylate kinase (MAGUK) proteins. Cypin, (Cytoplasmic PSD-95 interactor, also designated guanine deaminase and nedasin S), regulates intermediate steps in postsynaptic protein sorting, such as synaptic clustering of MAGUK proteins, and associates with multiple members of the PSD-95 family. Expressed both pre- and post-synaptically, cypin is most prevalent within the cytoplasm of dendritic shafts and in the neck of synaptic spines. In non-neuronal cells, cypin is most highly expressed in the basal membrane of intestinal epithelial cells. Cypin is also highly expressed in kidney, liver, lung, brain, and spleen, with lower levels of expression in placenta, heart, and skeletal muscle. Native cypin may also be expressed as a dimer and a tetramer.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 51kDa
NCBI Official Full Name
guanine deaminase isoform a
NCBI Official Synonym Full Names
guanine deaminase
NCBI Official Symbol
GDA
NCBI Official Synonym Symbols
GAH; CYPIN; GUANASE; NEDASIN
NCBI Protein Information
guanine deaminase
UniProt Protein Name
Guanine deaminase
UniProt Gene Name
GDA
UniProt Synonym Gene Names
KIAA1258; Guanase; Guanine aminase; GAH
UniProt Entry Name
GUAD_HUMAN
NCBI Description
This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
GDA: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Belongs to the ATZ/TRZ family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.4.3; Nucleotide Metabolism - purine; Hydrolase
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: intracellular; cytosol
Molecular Function: guanine deaminase activity; zinc ion binding
Biological Process: nervous system development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; guanine catabolic process; purine base metabolic process
Research Articles on GDA
1. This protein has been found differentially expressed in thalami from patients with schizophrenia.
Similar Products
Product Notes
The GDA gda (Catalog #AAA3011575) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GDA Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GDA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:100. Researchers should empirically determine the suitability of the GDA gda for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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