Western Blot (WB)
(Western blot analysis of GAS6 expression in SW480 (A), COLO205 (B) whole cell lysates.)
Rabbit anti-Human GAS6 Polyclonal Antibody | anti-GAS6 antibody
Anti-GAS6 Antibody
Western Blot (WB)
(Western blot analysis of GAS6 expression in SW480 (A), COLO205 (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of GAS6 expression in SW480 (A), COLO205 (B) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GAS6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GAS6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Uniprot Description
GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen
Molecular Function: calcium ion binding; caspase inhibitor activity; molecular adaptor activity; phosphatidylserine binding; protein binding; protein tyrosine kinase activator activity; receptor agonist activity; receptor binding; receptor tyrosine kinase binding; voltage-gated calcium channel activity
Biological Process: activation of protein kinase B; apoptotic cell clearance; blood coagulation; cell adhesion; cell cycle arrest; cell migration; cell proliferation; cell-substrate adhesion; cellular protein metabolic process; cellular response to starvation; entry of virus into host cell; enzyme linked receptor protein signaling pathway; ER to Golgi vesicle-mediated transport; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of interferon-gamma production; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 production; negative regulation of protein import into nucleus, translocation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; neuron migration; organ regeneration; peptidyl-glutamic acid carboxylation; peptidyl-serine phosphorylation; phagocytosis; platelet activation; platelet degranulation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of fibroblast proliferation; positive regulation of glomerular filtration; positive regulation of natural killer cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phagocytosis; positive regulation of protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; post-translational protein modification; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of growth; signal peptide processing; signal transduction; viral envelope fusion with host membrane; viral genome replication; virion attachment, binding of host cell surface receptor
Research Articles on GAS6
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Product Notes
The GAS6 gas6 (Catalog #AAA8242146) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GAS6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GAS6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the GAS6 gas6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAS6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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