Rabbit anti-Human GAS6 Polyclonal Antibody | anti-GAS6 antibody

GAS6 Antibody

Cat. Num. AAA9406639

• Gene Names: GAS6; AXSF; AXLLG
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: GAS6; Polyclonal Antibody; GAS6 Antibody; AXSF; AXLLG; anti-GAS6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total GAS6 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.4 mg/ml (varies by lot)
• Sequence Length: 678

• Applicable Applications for anti-GAS6 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:10-1:50
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human growth arrest-specific 6
• Target Name: GAS6
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using at dilution 1/10.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/10.)

Related Product Information for anti-GAS6 antibody

This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Product Categories/Family for anti-GAS6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557617
• NCBI GeneID: 2621
• NCBI Accession #: NP_000811.1
• NCBI GenBank Nucleotide #: NM_000820.3
• UniProt Accession #: Q14393; Q6IMN1; Q7Z7N3; B3KRQ7; B3KVL4; E9PBL7
• Molecular Weight: 41,986 Da
• NCBI Official Full Name: growth arrest-specific protein 6
• NCBI Official Synonym Full Names: growth arrest-specific 6
• NCBI Official Symbol: GAS6
• NCBI Official Synonym Symbols: AXSF; AXLLG
• NCBI Protein Information: growth arrest-specific protein 6
• UniProt Protein Name: Growth arrest-specific protein 6
• Protein Family: Growth arrest-specific protein
• UniProt Gene Name: GAS6
• UniProt Synonym Gene Names: AXLLG; GAS-6
• UniProt Entry Name: GAS6_HUMAN

NCBI Description

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

Uniprot Description

GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligand, receptor tyrosine kinase; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; cytoplasm; extracellular region

Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding

Biological Process: proteolysis; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; positive regulation of phagocytosis; regulation of growth; negative regulation of interleukin-6 production; cell cycle arrest; cell adhesion; positive regulation of TOR signaling pathway; platelet activation; organ regeneration; negative regulation of transcription factor activity; activation of protein kinase B; cellular response to starvation; peptidyl-glutamic acid carboxylation; negative regulation of transcription, DNA-dependent; negative regulation of interleukin-1 secretion; leukocyte migration; negative regulation of apoptosis; entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; platelet degranulation; positive regulation of glomerular filtration; negative regulation of interferon-gamma production; protein kinase B signaling cascade; virion attachment, binding of host cell surface receptor; cell migration; viral genome replication; negative regulation of tumor necrosis factor production; post-translational protein modification; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; apoptotic cell clearance