Rabbit anti-Human GADD45GIP1 Polyclonal Antibody | anti-GADD45GIP1 antibody

GADD45GIP1 polyclonal antibody

Cat. Num. AAA3000550

• Gene Names: GADD45GIP1; PRG6; CRIF1; PLINP; CKBBP2; Plinp1; PLINP-1
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GADD45GIP1; Polyclonal Antibody; GADD45GIP1 polyclonal antibody; PLINP1; PRG6; Growth arrest and DNA damage-inducible proteins-interacting protein 1; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive; anti-GADD45GIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: CRIF1 Polyclonal Antibody detects endogenous levels of CRIF1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-GADD45GIP1 antibody: Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin section), ELISA (EIA)
• Application Notes: IHC: 1/100-1/300; ELISA: 1/40,000
• Immunogen: The antiserum was produced against synthesized peptide derived from human GADD45GIP1. AA range: 91-140
• Preparation and Storage: Store at 4 degee C for short term. Aliquot and store at -20 degee C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain, using GADD45GIP1 Antibody. The picture on the right is blocked with the synthesized peptide.)

Related Product Information for anti-GADD45GIP1 antibody

Background: GADD45G interacting protein 1(GADD45GIP1) Homo sapiens. This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

NCBI and Uniprot Product Information

• NCBI GI #: 31543415
• NCBI GeneID: 90480
• NCBI Accession #: NP_443082.2
• NCBI GenBank Nucleotide #: NM_052850.3
• UniProt Accession #: Q8TAE8; Q8IVM3; Q8TE51; Q969P9; Q9BSM6
• Molecular Weight: 25,384 Da
• NCBI Official Full Name: growth arrest and DNA damage-inducible proteins-interacting protein 1
• NCBI Official Synonym Full Names: growth arrest and DNA-damage-inducible, gamma interacting protein 1
• NCBI Official Symbol: GADD45GIP1
• NCBI Official Synonym Symbols: PRG6; CRIF1; PLINP; CKBBP2; Plinp1; PLINP-1
• NCBI Protein Information: growth arrest and DNA damage-inducible proteins-interacting protein 1; CR6 interacting factor 1; CKII beta binding protein 2; CKII beta-associating protein; p53-responsive gene 6 protein; papillomavirus L2 interacting nuclear protein 1; growth arrest- and
• UniProt Protein Name: Growth arrest and DNA damage-inducible proteins-interacting protein 1
• Protein Family: Growth arrest and DNA damage-inducible protein
• UniProt Gene Name: GADD45GIP1
• UniProt Synonym Gene Names: PLINP1; PRG6; CRIF1; PLINP; PLINP-1
• UniProt Entry Name: G45IP_HUMAN

NCBI Description

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

Uniprot Description

GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrion; mitochondrial matrix; nucleus

Molecular Function: protein binding

Biological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle