Goat anti-Human, Mouse GADD45G, aa123-133 Polyclonal Antibody | anti-GADD45G antibody

GADD45G, aa123-133 (GADD45 gamma, Growth arrest and DNA-damage-inducible, gamma, CR6, DDIT2, GRP17)

Cat. Num. AAA621280

• Gene Names: GADD45G; CR6; DDIT2; GRP17; GADD45gamma
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: GADD45G; aa123-133; Polyclonal Antibody; aa123-133 (GADD45 gamma; Growth arrest and DNA-damage-inducible; gamma; CR6; DDIT2; GRP17); Anti -GADD45G; anti-GADD45G antibody

• Host: Goat
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes human GADD45gamma. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-GADD45G antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: Peptide ELISA: 1:4,000.; Western Blot: Preliminary experiments in lysates of cell line A549 gave no specific signal but low background (at antibody concentration up to 1ug/ml). Optimal dilutions to be determined by the researcher.
• Immunogen: A synthetic peptide from the C-terminus of aa--SNPNEDAWKDP
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-GADD45G antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 5729836
• NCBI GeneID: 10912
• NCBI Accession #: NP_006696.1
• NCBI GenBank Nucleotide #: NM_006705.3
• UniProt Accession #: O95257; Q9C076; Q5MAI3; Q5VZ87; Q5VZ88; Q6IAW6; Q9UJS2
• Molecular Weight: 17,121 Da
• NCBI Official Full Name: growth arrest and DNA damage-inducible protein GADD45 gamma
• NCBI Official Synonym Full Names: growth arrest and DNA-damage-inducible, gamma
• NCBI Official Symbol: GADD45G
• NCBI Official Synonym Symbols: CR6; DDIT2; GRP17; GADD45gamma
• NCBI Protein Information: growth arrest and DNA damage-inducible protein GADD45 gamma; DDIT-2; GADD45-gamma; OTTHUMP00000021623; OTTHUMP00000021624; gadd-related protein, 17 kD; cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein
• UniProt Protein Name: Growth arrest and DNA damage-inducible protein GADD45 gamma
• Protein Family: Growth arrest and DNA damage-inducible protein
• UniProt Gene Name: GADD45G
• UniProt Synonym Gene Names: CR6; DDIT2
• UniProt Entry Name: GA45G_HUMAN

NCBI Description

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq]

Uniprot Description

GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.

Protein type: Nuclear receptor co-regulator; Apoptosis; DNA repair, damage

Chromosomal Location of Human Ortholog: 9q22.1-q22.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: activation of MAPKK activity; apoptosis; regulation of cell cycle; positive regulation of apoptosis; multicellular organismal development; activation of MAPKKK activity; response to stress; negative regulation of protein kinase activity; positive regulation of JNK cascade; cell differentiation