Rabbit GABARAPL1 Polyclonal Antibody | anti-GABARAPL1 antibody

GABARAPL1 Rabbit Polyclonal

Cat. Num. AAA769507

• Gene Names: GABARAPL1; ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GABARAPL1; Polyclonal Antibody; GABARAPL1 Rabbit Polyclonal; anti-GABARAPL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 117

• Applicable Applications for anti-GABARAPL1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: GABA(A) receptor-associated protein like 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor using MBS769507 (GABARAPL1 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS769507 (GABARAPL1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 13899219
• NCBI GeneID: 23710
• NCBI Accession #: NP_113600.1
• NCBI GenBank Nucleotide #: NM_031412.2
• Molecular Weight: 17,008 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor-associated protein-like 1
• NCBI Official Synonym Full Names: GABA type A receptor associated protein like 1
• NCBI Official Symbol: GABARAPL1
• NCBI Official Synonym Symbols: ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE
• NCBI Protein Information: gamma-aminobutyric acid receptor-associated protein-like 1
• UniProt Protein Name: Gamma-aminobutyric acid receptor-associated protein-like 1
• Protein Family: Gamma-aminobutyric acid receptor-associated protein
• UniProt Gene Name: GABARAPL1
• UniProt Synonym Gene Names: GEC1; GEC-1
• UniProt Entry Name: GBRL1_HUMAN

Uniprot Description

GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1.

Protein type: Autophagy; Ubiquitin-like modifier; Microtubule-binding; Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: autophagic vacuole; cytoplasmic vesicle membrane; cytosol; dendrite cytoplasm; endoplasmic reticulum; Golgi apparatus; intracellular; microtubule; mitochondrion

Molecular Function: beta-tubulin binding; GABA receptor binding; protein binding; Tat protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy; mitochondrion degradation