Rabbit anti-Human FUSIP1 Polyclonal Antibody | anti-FUSIP1 antibody

FUSIP1, CT (SRSF10, FUSIP1, FUSIP2, SFRS13A, TASR, Serine/arginine-rich splicing factor 10, 40kD SR-repressor protein, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, Splicing factor, arginine/serine-rich 13A, TLS-associated protein

Cat. Num. AAA6300344

• Gene Names: SRSF10; NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FUSIP1; Polyclonal Antibody; CT (SRSF10; FUSIP2; SFRS13A; TASR; Serine/arginine-rich splicing factor 10; 40kD SR-repressor protein; FUS-interacting serine-arginine-rich protein 1; Splicing factor SRp38; Splicing factor; arginine/serine-rich 13A; TLS-associated protein; SRSF10; TLS-associated protein with Ser-Arg repeats; TLS-associated serine-arginine protein; anti-FUSIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 173

• Applicable Applications for anti-FUSIP1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FUSIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human FUSIP1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FUSIP1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FUSIP1 antibody detected the FUSIP1 protein (arrow).)

Related Product Information for anti-FUSIP1 antibody

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.

Product Categories/Family for anti-FUSIP1 antibody

Antibodies; Splicing Factors

References

Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010). Ling, I.F., et al. Hum. Mutat. 31(6):702-709(2010). Shi, Y., et al. Mol. Cell 28(1):79-90(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Lareau, L.F., et al. Nature 446(7138):926-929(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 300360545
• NCBI GeneID: 10772
• NCBI Accession #: NP_001177935.1; NP_001177934.1
• NCBI GenBank Nucleotide #: NP_001177935.1
• UniProt Accession #: O75494
• NCBI Official Full Name: serine/arginine-rich splicing factor 10 isoform 4
• NCBI Official Synonym Full Names: serine and arginine rich splicing factor 10
• NCBI Official Symbol: SRSF10
• NCBI Official Synonym Symbols: NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
• NCBI Protein Information: serine/arginine-rich splicing factor 10
• UniProt Protein Name: Serine/arginine-rich splicing factor 10
• UniProt Gene Name: SRSF10
• UniProt Synonym Gene Names: FUSIP1; FUSIP2; SFRS13A; TASR
• UniProt Entry Name: SRS10_HUMAN

NCBI Description

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]