Rabbit anti-Human Frizzled Polyclonal Antibody | anti-fz antibody
Frizzled antibody
Gene Names
fz; CG17697; CG3646; dFz; Dfz; DFz; Dfz1; DFz1; DFZ1; Dm Fz1; DmelCG17697; frz; Frz; Fz; FZ; fz1; Fz1; fz[[1]]
Reactivity
Human
Applications
Immunohistochemistry
Purity
Frizzled antibody was purified by affinity chromatography.
Synonyms
Frizzled; Polyclonal Antibody; Frizzled antibody; Polyclonal Frizzled; Anti-Frizzled; FzE6; frizzled-9; Frizzled (Drosophila) homolog 3; hFz9; Fz9; fzd9; Frizzled 9; frizzled homolog fzd3; FZD3; anti-fz antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human
Purity/Purification
Frizzled antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
612
Applicable Applications for anti-fz antibody
Immunohistochemistry (IHC) Paraffin
Application Notes
IHC-P: 10 ug/ml
Biological Significance
Frizzled-9 is a protein that in humans is encoded by the FZD9 gene. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
Frizzled antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-fz antibody
Rabbit polyclonal Frizzled antibody
Product Categories/Family for anti-fz antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,118 Da
NCBI Official Full Name
frizzled, isoform C
NCBI Official Synonym Full Names
frizzled
NCBI Official Symbol
fz
NCBI Official Synonym Symbols
CG17697; CG3646; dFz; Dfz; DFz; Dfz1; DFz1; DFZ1; Dm Fz1; DmelCG17697; frz; Frz; Fz; FZ; fz1; Fz1; fz[[1]]
NCBI Protein Information
CG17697 gene product from transcript CG17697-RA
UniProt Protein Name
Frizzled
Protein Family
UniProt Gene Name
fz
UniProt Synonym Gene Names
dFz1
UniProt Entry Name
FRIZ_DROME
Uniprot Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Research Articles on fz
Similar Products
Product Notes
The fz fz (Catalog #AAA535473) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Frizzled antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Frizzled can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin. IHC-P: 10 ug/ml. Researchers should empirically determine the suitability of the fz fz for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Frizzled, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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