Rabbit FPR1 / FPR Polyclonal Antibody | anti-FPR1 antibody

Rabbit Polyclonal to Human FPR1 / FPR

Cat. Num. AAA247941

• Gene Names: FPR1; FPR; FMLP
• Reactivity: Chimpanzee, Gorilla, Human; Predicted Reactivity: Orangutan (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: FPR1 / FPR; Polyclonal Antibody; Rabbit Polyclonal to Human FPR1 / FPR; Anti-FPR1 / FPR Antibody (Extracellular Domain) IHC-plus; FPR1; FPR-1; FMet-Leu-Phe receptor; FMLP; Formyl peptide receptor 1; FPR; N-formyl peptide receptor; FMLP receptor; Fpr receptor; N-formyl peptide receptor 1; Human FPR1; anti-FPR1 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Gorilla, Human; Predicted Reactivity: Orangutan (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 350

• Applicable Applications for anti-FPR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from 3rd extracellular domain of human FPR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (94%); Gibbon (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: FPR1 / FPR antibody was raised against synthetic 18 amino acid peptide from 3rd extracellular domain of human FPR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (94%); Gibbon (83%).
• Antigen Modification: Extracellular Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-FPR1 antibody IHC of human spleen, red pulp. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-FPR1 antibody

Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection.

Product Categories/Family for anti-FPR1 antibody

Family: GPCR; Subfamily: Chemoattractant

NCBI and Uniprot Product Information

• NCBI GI #: 4503779
• NCBI GeneID: 2357
• NCBI Accession #: NP_002020.1
• NCBI GenBank Nucleotide #: NM_002029.3
• UniProt Accession #: P21462; Q14939; Q7Z6A4; Q86U52; Q9NS48
• Molecular Weight: 38,446 Da
• NCBI Official Full Name: fMet-Leu-Phe receptor
• NCBI Official Synonym Full Names: formyl peptide receptor 1
• NCBI Official Symbol: FPR1
• NCBI Official Synonym Symbols: FPR; FMLP
• NCBI Protein Information: fMet-Leu-Phe receptor; fMLP receptor; N-formylpeptide chemoattractant receptor
• UniProt Protein Name: fMet-Leu-Phe receptor
• Protein Family: FK506-binding protein
• UniProt Gene Name: FPR1
• UniProt Synonym Gene Names: fMLP receptor; FPR
• UniProt Entry Name: FPR1_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Uniprot Description

FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane; endosome

Molecular Function: RAGE receptor binding; protein binding; N-formyl peptide receptor activity; receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; activation of MAPK activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); chemotaxis; signal transduction; cell motility; nitric oxide mediated signal transduction