Rabbit anti-Human FPR1 Polyclonal Antibody | anti-FPR1 antibody

FPR1, ID (FPR1, fMet-Leu-Phe receptor, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor) (FITC)

Cat. Num. AAA6300040

• Gene Names: FPR1; FPR; FMLP
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: FPR1; Polyclonal Antibody; ID (FPR1; fMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor) (FITC); N-formylpeptide chemoattractant receptor; anti-FPR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FPR1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-FPR1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 165-193 in the central region of human FPR1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in A549 cell line lysates (35ug/lane) usingMBS6002295. This demonstrates that MBS6002295 detected the FPR1 protein (arrow).)

Related Product Information for anti-FPR1 antibody

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.

Product Categories/Family for anti-FPR1 antibody

Antibodies; Receptors

References

1. Davila, S., et al. Genes Immun. 11(3):232-238(2010). 2. Huang, J., et al. Br. J. Cancer 102(6):1052-1060(2010). 3. Segat, L., et al. Vaccine 28(10):2201-2206(2010). 4. Zhu, X.L., et al. Beijing Da Xue Xue Bao 41(6):664-668(2009). 5. Kobayashi, T., et al. J. Dent. Res. 88(12):1137-1141(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4503779
• NCBI GeneID: 2357
• NCBI Accession #: NP_002020.1; NP_001180235.1
• NCBI GenBank Nucleotide #: NM_002029.3
• UniProt Accession #: P21462; Q14939; Q7Z6A4; Q86U52; Q9NS48
• Molecular Weight: 38,446 Da
• NCBI Official Full Name: fMet-Leu-Phe receptor
• NCBI Official Synonym Full Names: formyl peptide receptor 1
• NCBI Official Symbol: FPR1
• NCBI Official Synonym Symbols: FPR; FMLP
• NCBI Protein Information: fMet-Leu-Phe receptor; fMLP receptor; N-formylpeptide chemoattractant receptor
• UniProt Protein Name: fMet-Leu-Phe receptor
• Protein Family: FK506-binding protein
• UniProt Gene Name: FPR1
• UniProt Synonym Gene Names: fMLP receptor; FPR
• UniProt Entry Name: FPR1_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Uniprot Description

FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane; endosome

Molecular Function: protein binding; RAGE receptor binding; N-formyl peptide receptor activity; receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; activation of MAPK activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); signal transduction; cell motility; chemotaxis; nitric oxide mediated signal transduction