Immunohistochemistry (IHC)
((20ug/ml) staining of paraffin embedded Human Thymus Medulla. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Goat FOXN1 Polyclonal Antibody | anti-FOXN1 antibody
Goat anti-FOXN1 Antibody
Immunohistochemistry: In paraffin embedded Human Thymus Medulla shows speculate nuclear staining in some of the Medullar cells. Recommended concentration, 20-30ug/ml.
Western Blot: Preliminary experiments in Human Thymus lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Immunohistochemistry (IHC)
((20ug/ml) staining of paraffin embedded Human Thymus Medulla. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Immunohistochemistry (IHC)
((20ug/ml) staining of paraffin embedded Human Thymus Medulla. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
NCBI and Uniprot Product Information
NCBI Description
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.
Protein type: DNA-binding; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: blood vessel morphogenesis; defense response; epidermis development; epithelial cell proliferation; hair follicle development; keratinocyte differentiation; organ morphogenesis; positive regulation of hair follicle development; regulation of transcription from RNA polymerase II promoter; T cell homeostasis; T cell lineage commitment; transcription from RNA polymerase II promoter
Disease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
Research Articles on FOXN1
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Product Notes
The FOXN1 foxn1 (Catalog #AAA420140) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-FOXN1 Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's FOXN1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Thymus Medulla shows speculate nuclear staining in some of the Medullar cells. Recommended concentration, 20-30ug/ml. Western Blot: Preliminary experiments in Human Thymus lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the FOXN1 foxn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SVYLSPSSKP VALA. It is sometimes possible for the material contained within the vial of "FOXN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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