Rabbit anti-Human FOXF1 Polyclonal Antibody | anti-FOXF1 antibody

FOXF1 (Forkhead Box F1, Drosophila Forkhead Homolog Like 5, FKHL5, Forkhead-Related Activator 1, FREAC1)

Cat. Num. AAA618795

• Gene Names: FOXF1; FKHL5; ACDMPV; FREAC1; MGC105125
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXF1; Polyclonal Antibody; FOXF1 (Forkhead Box F1; Drosophila Forkhead Homolog Like 5; FKHL5; Forkhead-Related Activator 1; FREAC1); Anti -FOXF1 (Forkhead Box F1; anti-FOXF1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXF1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-FOXF1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA Titer: 1:250,000
• Immunogen: Synthetic peptide (C-ASSGPSKAKKTNA) corresponding to human FOXF1 (KLH). Molecular Weight: 38kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-FOXF1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 110735445
• NCBI GeneID: 2294
• NCBI Accession #: NP_001442.2
• NCBI GenBank Nucleotide #: NM_001451.2
• UniProt Accession #: Q12946; Q5FWE5; B2RAF4
• Molecular Weight: 40,122 Da
• NCBI Official Full Name: forkhead box protein F1
• NCBI Official Synonym Full Names: forkhead box F1
• NCBI Official Symbol: FOXF1
• NCBI Official Synonym Symbols: FKHL5; ACDMPV; FREAC1; MGC105125
• NCBI Protein Information: forkhead box protein F1; FREAC-1; OTTHUMP00000175006; forkhead-related activator 1; forkhead-related protein FKHL5; Forkhead, drosophila, homolog-like 5; forkhead-related transcription factor 1
• UniProt Protein Name: Forkhead box protein F1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXF1
• UniProt Synonym Gene Names: FKHL5; FREAC1
• UniProt Entry Name: FOXF1_HUMAN

NCBI Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq]

Uniprot Description

FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.

Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; DNA binding; sequence-specific DNA binding

Biological Process: transcription from RNA polymerase II promoter; extracellular matrix organization and biogenesis; positive regulation of transcription, DNA-dependent; negative regulation of mast cell degranulation; heart development; establishment of epithelial cell polarity; negative regulation of transcription from RNA polymerase II promoter; lateral mesodermal cell differentiation; cell-cell adhesion; embryonic digestive tract morphogenesis; positive regulation of mesenchymal cell proliferation; embryonic foregut morphogenesis; regulation of smooth muscle cell differentiation; pancreas development; detection of wounding; vasculogenesis; blood vessel development; smoothened signaling pathway; somitogenesis; in utero embryonic development; respiratory tube development; morphogenesis of a branching structure; gut development; negative regulation of inflammatory response; midgut development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic ectodermal gut morphogenesis; determination of left/right symmetry; alveolus development; lung development; positive regulation of cell migration

Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins