Western Blot (WB)
(Anti-Fos B antibody, MBS175378, Western blottingLane 1: HT1080 Cell LysateLane 2: SW620 Cell LysateLane 3: HELA Cell LysateLane 4: SMMC Cell LysateLane 5: MM453 Cell Lysate )
Rabbit Fos B Polyclonal Antibody | anti-FOSB antibody
Anti-Fos B antibody
Western Blot (WB)
(Anti-Fos B antibody, MBS175378, Western blottingLane 1: HT1080 Cell LysateLane 2: SW620 Cell LysateLane 3: HELA Cell LysateLane 4: SMMC Cell LysateLane 5: MM453 Cell Lysate )
Western Blot (WB)
(Anti-Fos B antibody, MBS175378, Western blottingLane 1: HT1080 Cell LysateLane 2: SW620 Cell LysateLane 3: HELA Cell LysateLane 4: SMMC Cell LysateLane 5: MM453 Cell Lysate )
Background: FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.
NCBI and Uniprot Product Information
NCBI Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
FosB: FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; response to drug; response to cAMP; response to mechanical stimulus; response to morphine; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; response to progesterone stimulus; response to corticosterone stimulus; cellular response to hormone stimulus
Research Articles on FOSB
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Product Notes
The FOSB fosb (Catalog #AAA175378) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Fos B antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Fos B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the FOSB fosb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fos B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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