Western Blot (WB)
(Western blot analysis of FOP expression in MCF7 (A), MDAMB231 (B), MDAMB435 (C), mouse brain (D), rat brain (E) whole cell lysates.)
Rabbit FOP Polyclonal Antibody | anti-FGFR1OP antibody
Anti-FOP Antibody
Western Blot (WB)
(Western blot analysis of FOP expression in MCF7 (A), MDAMB231 (B), MDAMB435 (C), mouse brain (D), rat brain (E) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of FOP expression in MCF7 (A), MDAMB231 (B), MDAMB435 (C), mouse brain (D), rat brain (E) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of FOP expression in THP1 (A), mouse testis (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of FOP expression in THP1 (A), mouse testis (B) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FOP staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FOP staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Uniprot Description
FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: centrosome; perinuclear region of cytoplasm; cytosol; nucleus
Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; protein kinase binding
Biological Process: peptidyl-tyrosine phosphorylation; organelle organization and biogenesis; positive regulation of cell proliferation; negative regulation of protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell growth; positive regulation of cell migration
Research Articles on FGFR1OP
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Product Notes
The FGFR1OP fgfr1op (Catalog #AAA822104) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FOP Antibody reacts with Human, Mouse, Rat, Bovine, Dog, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's FOP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB (1/500 - 1/1000), IH (1/100 - 1/200). Researchers should empirically determine the suitability of the FGFR1OP fgfr1op for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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