Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate;;Lane 2: FOLR1 knockout Hela cell lysate;;Predicted MW: 30kDa ;Observed MW: 35kDa;Primary Ab: 1ug/ml Rabbit Anti-Human FOLR1 Ab;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Rabbit anti-Human Folate Receptor 1, Adult (FOLR1) Polyclonal Antibody | anti-FOLR1 antibody
Biotin-Linked Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate;;Lane 2: FOLR1 knockout Hela cell lysate;;Predicted MW: 30kDa ;Observed MW: 35kDa;Primary Ab: 1ug/ml Rabbit Anti-Human FOLR1 Ab;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate;;Lane 2: FOLR1 knockout Hela cell lysate;;Predicted MW: 30kDa ;Observed MW: 35kDa;Primary Ab: 1ug/ml Rabbit Anti-Human FOLR1 Ab;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Description
FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: anchored component of external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; brush border membrane; cell surface; clathrin-coated vesicle; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; endosome; Golgi membrane; integral component of plasma membrane; membrane; nucleus; plasma membrane; transport vesicle
Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding; receptor activity
Biological Process: axon regeneration; COPII vesicle coating; ER to Golgi vesicle-mediated transport; folic acid metabolic process; folic acid transport; heart looping; receptor-mediated endocytosis; regulation of transforming growth factor beta receptor signaling pathway
Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency
Research Articles on FOLR1
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Product Notes
The FOLR1 folr1 (Catalog #AAA2095984) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Folate Receptor 1, Adult (FOLR1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Folate Receptor 1, Adult (FOLR1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the FOLR1 folr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Folate Receptor 1, Adult (FOLR1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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