Western Blot (WB)
(Western blot analysis of FLI1 in Jurkat cell lysate with FLI1 antibody at (A) 0.5 and (B) 1 μg/ml.)
Rabbit FLI1 Polyclonal Antibody | anti-FLI1 antibody
FLI1 Antibody
Western Blot (WB)
(Western blot analysis of FLI1 in Jurkat cell lysate with FLI1 antibody at (A) 0.5 and (B) 1 μg/ml.)
Western Blot (WB)
(Western blot analysis of FLI1 in Jurkat cell lysate with FLI1 antibody at (A) 0.5 and (B) 1 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of FLI1 in HeLa cells with MUC1 antibody at 5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of FLI1 in HeLa cells with MUC1 antibody at 5 μg/mL.)
NCBI and Uniprot Product Information
Observed: 52kDa
NCBI Description
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Description
FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasmic membrane-bound vesicle; intermediate filament; nucleus
Molecular Function: protein binding; calcium ion binding; structural molecule activity
Biological Process: keratinocyte differentiation; multicellular organismal development
Disease: Ichthyosis Vulgaris; Dermatitis, Atopic, 2
Research Articles on FLI1
Similar Products
Product Notes
The FLI1 fli1 (Catalog #AAA153604) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FLI1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FLI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). FLI1 antibody can be used for detection of FLI1 by Western blot at 0.5 - 1 mug/ml. Researchers should empirically determine the suitability of the FLI1 fli1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FLI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
